|
Extraordinary Measures
|
| 00:00:33 |
(PEOPLE CHATTERING) |
| 00:00:39 |
Hi there. |
| 00:00:41 |
So glad to see you. |
| 00:00:43 |
Kathy, could you take that? |
| 00:00:46 |
Thank you. |
| 00:00:48 |
JOHN: |
| 00:00:50 |
Bristol-Myers, and I'm telling you, |
| 00:00:51 |
kids won't go for it unless |
| 00:00:55 |
Mr. Crowley, you're late. |
| 00:00:56 |
All right. |
| 00:01:14 |
AILEEN: |
| 00:01:16 |
"'Why won't anyone buy our newspaper?' |
| 00:01:20 |
"'They must be rock haters, |
| 00:01:23 |
MEGAN: |
| 00:01:25 |
JOHN JR.: |
| 00:01:27 |
Give me a minute, okay? |
| 00:01:29 |
Give it back to me, John! |
| 00:01:30 |
You save our spot. Got it? |
| 00:01:32 |
You better give me |
| 00:01:36 |
Help, Mom! |
| 00:01:38 |
Help me! She's trying to kill me! |
| 00:01:40 |
I'm gonna get you! |
| 00:01:42 |
You can't escape! |
| 00:01:43 |
No! Mom, help me! |
| 00:01:45 |
(GIGGLES) |
| 00:01:48 |
Mom! She's trying to kill me! |
| 00:01:50 |
Megan Kathryn Crowley. |
| 00:01:55 |
If you kill your brother, |
| 00:01:58 |
Why not? He stole Fiona. |
| 00:02:00 |
I didn't steal her, I kidnapped her. |
| 00:02:04 |
Release the victim. |
| 00:02:06 |
(GRUNTS) |
| 00:02:08 |
Time to get ready for your party. |
| 00:02:10 |
JOHN: We've got to get |
| 00:02:13 |
PETE ON PHONE: |
| 00:02:14 |
Damn it! |
| 00:02:16 |
I just missed my train. |
| 00:02:18 |
I agree. |
| 00:02:20 |
As soon as possible. |
| 00:02:25 |
AILEEN: John, we're loading up |
| 00:02:28 |
Okay, we ready to roll, Kate? |
| 00:02:30 |
My name is Jane. |
| 00:02:31 |
Kate was yesterday, Mom. |
| 00:02:32 |
Oh, I am so sorry. |
| 00:02:34 |
The way the agency |
| 00:02:36 |
you'd think they'd, you know, |
| 00:02:39 |
Mmm-hmm. |
| 00:02:41 |
Okay, John. |
| 00:02:43 |
John, come on, get |
| 00:02:46 |
John. |
| 00:02:48 |
Are you bringing your RipStik? |
| 00:02:49 |
Do you have to? |
| 00:02:54 |
JOHN: ...a pain, that's why. |
| 00:02:56 |
Hi. Come here. |
| 00:03:02 |
Daddy's meeting |
| 00:03:04 |
AILEEN: |
| 00:03:06 |
I am sure he has |
| 00:03:10 |
JOHN: |
| 00:03:19 |
DRIVER: |
| 00:03:21 |
Great. I'm sorry, |
| 00:03:34 |
Go. |
| 00:03:37 |
Come on, come on, come on... |
| 00:03:41 |
(KIDS CHEERING) |
| 00:03:55 |
KIDS: |
| 00:03:57 |
He totally promised |
| 00:03:59 |
He's on his way, baby. |
| 00:04:01 |
ALL: |
| 00:04:06 |
* Happy birthday to you |
| 00:04:11 |
* Happy birthday, dear Megan |
| 00:04:15 |
(LAUGHING) |
| 00:04:17 |
Get in there and give her a kiss. |
| 00:04:18 |
I don't wanna hear it... |
| 00:04:21 |
Happy birthday. |
| 00:04:24 |
Yay! |
| 00:04:27 |
Make a wish, Megan. |
| 00:04:29 |
(KIDS CHEERING) |
| 00:04:32 |
Who wants cake? |
| 00:04:33 |
KIDS: |
| 00:04:35 |
Line up single file, |
| 00:04:39 |
All right, |
| 00:04:40 |
I'm first! |
| 00:04:43 |
No, I'm the big guy. |
| 00:04:44 |
GIRL: |
| 00:04:54 |
So, where is Fiona |
| 00:04:59 |
Lollipop Land? |
| 00:05:02 |
I'm 8, Daddy. |
| 00:05:08 |
She's driving to Antarctica |
| 00:05:11 |
Really? |
| 00:05:13 |
That's pretty far away. |
| 00:05:17 |
Why doesn't she just go |
| 00:05:20 |
They have a lot of |
| 00:05:21 |
Haven't you ever |
| 00:05:24 |
Yeah. |
| 00:05:26 |
It's gonna take her years. |
| 00:05:30 |
Won't she need a suitcase? |
| 00:05:32 |
It's an adventure. You don't |
| 00:05:35 |
Well, I don't know about you, |
| 00:05:37 |
I would take a suitcase. |
| 00:05:38 |
That's 'cause you're a businessman. |
| 00:05:40 |
That's right. I am. |
| 00:05:43 |
And you're 8 years old. |
| 00:05:47 |
Love you, too, Daddy. |
| 00:05:50 |
Good night. |
| 00:05:53 |
Good night. |
| 00:05:55 |
Nighty-night. |
| 00:05:59 |
Sweet dreams. |
| 00:06:05 |
Good night, Dad. |
| 00:06:14 |
Good night, Daddy. |
| 00:07:45 |
(PHONE RINGING) |
| 00:07:46 |
(TRUCKIN' PLAYING) |
| 00:07:48 |
* One of these days |
| 00:07:51 |
* Out of the door and |
| 00:07:54 |
* Truckin', |
| 00:07:58 |
* Once told me |
| 00:08:02 |
* Sometimes the cards |
| 00:08:06 |
* If you don't lay 'em down |
| 00:08:13 |
(PHONE CONTINUES RINGING) |
| 00:08:23 |
Hello? |
| 00:08:27 |
Are you there? Hello? |
| 00:08:29 |
Yeah. |
| 00:08:31 |
This is John Crowley. |
| 00:08:32 |
I don't know if you've gotten |
| 00:08:35 |
Who? |
| 00:08:37 |
Jesus. |
| 00:08:38 |
I'm interested in |
| 00:08:40 |
I understand from |
| 00:08:44 |
having a conversation |
| 00:08:47 |
Is this a good time to talk? |
| 00:08:51 |
Dr. Stonehill? Hello? |
| 00:08:57 |
Asshole. |
| 00:08:59 |
"Asshole?" |
| 00:09:42 |
AILEEN: The night nurse |
| 00:09:46 |
What time is it? |
| 00:09:50 |
I missed you. |
| 00:09:54 |
This is pathetic. |
| 00:09:58 |
I could help you with that. |
| 00:10:01 |
Oh? |
| 00:10:05 |
(AILEEN MOANING) |
| 00:10:17 |
Oh my...Kate! |
| 00:10:19 |
You're early. |
| 00:10:21 |
Have you met... |
| 00:10:26 |
John is my husband. |
| 00:10:28 |
Glad to hear it. |
| 00:10:30 |
JOHN: |
| 00:10:43 |
(MECHANICAL BEEPING) |
| 00:10:48 |
AILEEN: Yeah, let's up her |
| 00:10:51 |
What's going on? |
| 00:10:52 |
Just a cold. |
| 00:10:56 |
Call the doc just to |
| 00:10:57 |
AILEEN: |
| 00:11:00 |
Sweetie? I'm gonna |
| 00:11:05 |
Feel better. |
| 00:11:08 |
Bye-bye. |
| 00:11:11 |
PETE: We're already doing great |
| 00:11:14 |
It's our direct marketing to patients |
| 00:11:17 |
Mr. Crowley, I'm really sorry. |
| 00:11:19 |
Aileen's on the line, |
| 00:11:22 |
Okay, thank you. |
| 00:11:24 |
We're at the hospital. |
| 00:11:28 |
Is she all right? |
| 00:11:29 |
Just keep |
| 00:11:31 |
Okay. Can I do something? |
| 00:11:33 |
I'll call you when I know more. |
| 00:11:34 |
I should really get back to Megan, |
| 00:11:36 |
as soon as I |
| 00:11:38 |
Bye. Love you. |
| 00:11:49 |
Excuse me, please. |
| 00:11:50 |
My daughter, Megan Crowley, |
| 00:11:52 |
was brought in for observation. |
| 00:11:53 |
Yeah. Actually, |
| 00:11:57 |
Where? |
| 00:12:00 |
Aileen. |
| 00:12:02 |
John. |
| 00:12:03 |
Has she told you |
| 00:12:05 |
that Fiona's taking with her |
| 00:12:07 |
Yeah, yes, she did. |
| 00:12:10 |
You're gonna see all the penguins, |
| 00:12:12 |
She might send some postcards |
| 00:12:15 |
Lots of good stuff to see along the way... |
| 00:12:17 |
like icebergs and |
| 00:12:21 |
How about some seals? |
| 00:12:43 |
DR. PRESTON: As you know, |
| 00:12:46 |
in every part of the body, |
| 00:12:48 |
so this sort of respiratory |
| 00:12:51 |
that's just an inevitable |
| 00:12:58 |
Mr. Crowley, Mrs. Crowley, |
| 00:13:03 |
Megan is not |
| 00:13:07 |
Okay? Now, we've done everything |
| 00:13:11 |
There's nothing more |
| 00:13:15 |
As you know, she was already |
| 00:13:20 |
for, you know, Pompe kids. |
| 00:13:22 |
After all, it's not |
| 00:13:26 |
Her heart, her liver, |
| 00:13:30 |
and would've |
| 00:13:34 |
Now, I wish that we had a drug |
| 00:13:36 |
but we simply don't. |
| 00:13:39 |
I'm so very sorry. |
| 00:13:43 |
Look, maybe... |
| 00:13:45 |
Maybe you can find |
| 00:13:47 |
in knowing that Megan's |
| 00:13:51 |
Maybe you can see |
| 00:14:03 |
(WHEEZING) |
| 00:14:27 |
(ALARM BEEPING) |
| 00:14:30 |
Megan? |
| 00:14:31 |
Help! Help! |
| 00:14:33 |
JOHN: |
| 00:14:35 |
Baby girl, can you hear me? |
| 00:14:37 |
Please, someone come help! |
| 00:14:39 |
Megan Crowley, room 321, please! |
| 00:14:41 |
Baby girl, Mama's here, all right? |
| 00:14:44 |
NURSE 1: Asystole! |
| 00:14:45 |
AILEEN: Can you hear my voice? |
| 00:14:47 |
DOCTOR 1: |
| 00:14:48 |
NURSE 2: |
| 00:14:49 |
Over here, please quickly. |
| 00:14:51 |
Hang in there, baby, okay? |
| 00:14:53 |
JOHN: Aileen? |
| 00:14:55 |
DOCTOR 2: |
| 00:14:56 |
Please, Mrs. Crowley, let... |
| 00:14:58 |
Let us help her! |
| 00:14:59 |
Please... Megan! |
| 00:15:01 |
DOCTOR 2: Epinephrine, 0.1 mils per kig. |
| 00:15:03 |
DOCTOR 1: |
| 00:15:05 |
Forget the weight, come on, |
| 00:15:08 |
NURSE 1: 0.1 epi. |
| 00:15:09 |
Come on, Megs. |
| 00:15:11 |
DOCTOR 1: Okay, just give |
| 00:15:13 |
NURSE 1: |
| 00:15:15 |
All right, charge the defib. |
| 00:15:42 |
Your daughter |
| 00:15:46 |
She's gonna be okay. |
| 00:15:47 |
Oh, my God. |
| 00:15:48 |
Now, look, she's still a very |
| 00:15:52 |
but her vital |
| 00:15:54 |
and I'm cautiously optimistic. |
| 00:15:59 |
So, I guess you could say |
| 00:16:10 |
Mrs. Crowley, |
| 00:16:12 |
Thanks so much. Thank you. |
| 00:16:49 |
PETE: Hey, John? |
| 00:16:53 |
Any time you're ready, man. |
| 00:16:56 |
You gonna tell us |
| 00:17:03 |
John, you okay? |
| 00:17:05 |
I have to go. |
| 00:17:08 |
John. |
| 00:17:11 |
Where you going? |
| 00:17:41 |
Excuse me, please. |
| 00:17:52 |
Best make yourself |
| 00:18:18 |
Oh, dear. |
| 00:18:19 |
Sir, sir. That's Dr. Stonehill. |
| 00:18:23 |
Thank you. |
| 00:18:25 |
Dr. Stonehill! |
| 00:18:30 |
Hey, Dr. Stonehill! |
| 00:19:23 |
(SPORTSCASTERS |
| 00:19:40 |
Dr. Stonehill? |
| 00:19:43 |
Yeah? |
| 00:19:44 |
I'm John Crowley. |
| 00:19:47 |
Okay. |
| 00:19:50 |
What messages? |
| 00:19:51 |
I left you 3 or 4 messages |
| 00:19:54 |
and you even hung up |
| 00:19:57 |
What the hell are you talking about? |
| 00:20:01 |
Dr. Stonehill, |
| 00:20:06 |
Oh, Jesus. |
| 00:20:10 |
Well, I'm sorry. |
| 00:20:13 |
A terrible disease, |
| 00:20:14 |
but, hell, you shouldn't have |
| 00:20:16 |
without talking to me. |
| 00:20:17 |
I do research, son. |
| 00:20:20 |
Well, it's your research |
| 00:20:23 |
I've read all the journal articles |
| 00:20:27 |
and all the researchers |
| 00:20:29 |
your work holds |
| 00:20:31 |
Get to the point, son. |
| 00:20:34 |
We almost lost my |
| 00:20:41 |
I need to hear |
| 00:20:48 |
STONEHILL: Your kids have |
| 00:20:52 |
They're missing an enzyme |
| 00:20:54 |
which metabolizes a certain kind |
| 00:20:58 |
It's defective |
| 00:21:01 |
So, this sugar builds up |
| 00:21:04 |
especially in the heart, |
| 00:21:08 |
which is why they have |
| 00:21:10 |
Yeah, I know. |
| 00:21:12 |
Everybody's making |
| 00:21:14 |
but you can infuse kids all day long |
| 00:21:18 |
and it's not |
| 00:21:19 |
'cause it's not gonna |
| 00:21:23 |
Understand what I'm saying? |
| 00:21:24 |
Yeah, so that means that |
| 00:21:25 |
Don't interrupt. |
| 00:21:27 |
I'm making a different version |
| 00:21:31 |
My enzyme has a biological marker, |
| 00:21:35 |
I'm the only one that's cloned the gene |
| 00:21:39 |
I'm the only one who's cloned the gene |
| 00:21:42 |
so I can get more mannose 6-phosphate |
| 00:21:46 |
and I can deliver a more effective |
| 00:21:52 |
into the cells. |
| 00:21:53 |
That's why people |
| 00:21:55 |
That's why you read my name |
| 00:21:57 |
I can get more |
| 00:22:02 |
What's the matter, Sal? |
| 00:22:07 |
I thought Doc was |
| 00:22:09 |
No, that man's a genius. He's on |
| 00:22:12 |
Wow. Who knew? |
| 00:22:16 |
I'm not on the |
| 00:22:18 |
This is a theory, |
| 00:22:20 |
I'm just an academic. |
| 00:22:22 |
You got any idea how |
| 00:22:24 |
No. |
| 00:22:27 |
University of Nebraska |
| 00:22:29 |
more money in a year |
| 00:22:32 |
Nobody's paying |
| 00:22:35 |
Half my grants |
| 00:22:37 |
I don't have the money to make |
| 00:22:43 |
How old are your kids? |
| 00:22:46 |
6 and 8. |
| 00:22:54 |
Look, do yourself a favor. |
| 00:23:01 |
Enjoy 'em while they're still here. |
| 00:23:11 |
How much? |
| 00:23:12 |
How much what? |
| 00:23:14 |
How much money would it take |
| 00:23:17 |
to create your version |
| 00:23:21 |
I'd need half a million bucks |
| 00:23:25 |
That's why you need me. |
| 00:23:26 |
I need you? Why? |
| 00:23:28 |
Because I'm the founder of the |
| 00:23:35 |
I've been working on this disease |
| 00:23:37 |
I have never |
| 00:23:40 |
That's because |
| 00:23:42 |
We're just in |
| 00:23:46 |
How soon do you |
| 00:23:48 |
Now would be good. |
| 00:23:49 |
Well, not all the money's in place, |
| 00:23:57 |
This is a very |
| 00:24:09 |
JOHN: Thanks. |
| 00:24:26 |
Hey. |
| 00:24:31 |
You okay? |
| 00:24:37 |
Did you get my messages? |
| 00:24:39 |
Your messages? |
| 00:24:42 |
You suddenly walk |
| 00:24:44 |
and fly to Nebraska |
| 00:24:47 |
and you think |
| 00:24:49 |
I'm sorry. |
| 00:24:52 |
I wanna find a miracle |
| 00:24:54 |
But how could you put |
| 00:24:57 |
Aileen. |
| 00:24:58 |
do we pay $40,000 a month in healthcare |
| 00:25:02 |
Honey, come on. |
| 00:25:03 |
Oh, really? |
| 00:25:04 |
Pete called here twice last night |
| 00:25:08 |
You know, mentally. |
| 00:25:10 |
(SCOFFS) |
| 00:25:17 |
I'll just... I'll call, and I'll |
| 00:25:21 |
Yeah, no shit. |
| 00:25:25 |
(SIGHS) |
| 00:25:28 |
I'm sorry. |
| 00:25:34 |
Something in me |
| 00:25:37 |
That night at the hospital, when we |
| 00:25:47 |
I prayed that if it was her time, |
| 00:25:54 |
she'd go quickly, |
| 00:26:02 |
But morning came, |
| 00:26:08 |
Her eyes, |
| 00:26:12 |
so determined, so defiant. |
| 00:26:16 |
The fight in her. |
| 00:26:24 |
(SIGHS) |
| 00:26:29 |
Was he worth it? |
| 00:26:32 |
He's really eccentric, |
| 00:26:34 |
is way ahead of |
| 00:26:36 |
He's definitely the one to put |
| 00:26:38 |
(CHUCKLES) |
| 00:26:40 |
I promised him |
| 00:26:42 |
because he's got this conference |
| 00:26:45 |
and I said I'd have |
| 00:26:47 |
How much? |
| 00:26:48 |
That's all? |
| 00:26:52 |
Is it $500 or $1,000? |
| 00:26:54 |
$500,000. |
| 00:26:58 |
By next month. |
| 00:27:03 |
(CHUCKLES) |
| 00:27:05 |
Sweetheart, are you totally insane? |
| 00:27:08 |
Apparently. |
| 00:27:10 |
AILEEN: We're holding our first fundraiser |
| 00:27:13 |
and we would love if |
| 00:27:15 |
Ready for your spelling test? |
| 00:27:17 |
I'm gonna nail it. |
| 00:27:18 |
My name's John Crowley. |
| 00:27:21 |
and I got your name from the |
| 00:27:25 |
Yeah. |
| 00:27:26 |
AILEEN: And I was so sorry |
| 00:27:29 |
because you were one of my most |
| 00:27:33 |
(CHUCKLES) |
| 00:27:34 |
Anyway, John and I |
| 00:27:37 |
Hey, Dad? Dad. |
| 00:27:39 |
Just make it right. |
| 00:27:41 |
Can't you see |
| 00:27:43 |
Okay, well, tell me he told you. |
| 00:27:46 |
No, I'm gonna have |
| 00:27:47 |
I can't talk. All right, bye. |
| 00:27:48 |
Yeah, what is it? |
| 00:27:50 |
Okay. |
| 00:27:52 |
Is it enough to give to Megan |
| 00:27:58 |
Yeah, it's more than enough. |
| 00:28:03 |
Are you John? |
| 00:28:05 |
Marcus Temple. |
| 00:28:07 |
Right. Absolutely. |
| 00:28:08 |
All the way in from Atlanta. |
| 00:28:11 |
Well, this is for your foundation, |
| 00:28:13 |
from my relatives, |
| 00:28:16 |
Oh! My goodness. |
| 00:28:18 |
(MARCUS CHUCKLES) |
| 00:28:19 |
JOHN: |
| 00:28:26 |
Thanks. |
| 00:28:47 |
Hi, Dr. Stonehill. |
| 00:28:49 |
Hi, Megan. |
| 00:28:52 |
Yeah, that's why I said, |
| 00:28:56 |
Are you coming in or not? |
| 00:28:58 |
Yeah, thanks. |
| 00:29:02 |
Where's Mom and Dad? |
| 00:29:03 |
They'll be down |
| 00:29:05 |
Patrick's vent alarm is going off, |
| 00:29:08 |
His alarm goes off |
| 00:29:19 |
So, what's your deal? |
| 00:29:24 |
Do you have a wife? |
| 00:29:26 |
Uh, ex-wives. 2 of 'em. |
| 00:29:28 |
Yeah? How come? |
| 00:29:30 |
'Cause I'm so easy |
| 00:29:33 |
Any other questions? |
| 00:29:34 |
No. Your turn to ask one. |
| 00:29:38 |
You're probably wondering |
| 00:29:40 |
What grade are you in? |
| 00:29:41 |
I'm in 3rd. |
| 00:29:43 |
My hobbies are video games and penguins. |
| 00:29:47 |
I already graduated. |
| 00:29:49 |
No, I mean hobbies. |
| 00:29:51 |
Oh... |
| 00:29:53 |
Mostly I just work. |
| 00:29:55 |
Little bass fishing |
| 00:30:00 |
What's your favorite subject? |
| 00:30:02 |
I'm good at reading, but I like P.E. best, |
| 00:30:06 |
Sprint races? |
| 00:30:08 |
Wanna see? |
| 00:30:09 |
Sure. |
| 00:30:15 |
Come on. |
| 00:30:19 |
Is he here yet? |
| 00:30:21 |
I don't know. |
| 00:30:31 |
I'm gonna win! |
| 00:30:33 |
Come on, slowpoke. |
| 00:30:40 |
Yeah, I won! |
| 00:30:41 |
(CHUCKLES) |
| 00:30:44 |
Oh, yeah. |
| 00:30:46 |
Told you I'm gonna beat you. |
| 00:30:49 |
Hi. |
| 00:30:52 |
Dr. Stonehill has 2 ex-wives. |
| 00:30:54 |
I see that Megan's introduced herself. |
| 00:30:57 |
How are you, Dr. Stonehill? |
| 00:30:59 |
This is Aileen, my wife. |
| 00:31:01 |
And John Jr. |
| 00:31:02 |
Hello. |
| 00:31:03 |
Here's Patrick. |
| 00:31:05 |
Hey, Patrick. |
| 00:31:08 |
AILEEN: |
| 00:31:09 |
Megan, we'll see you inside. |
| 00:31:17 |
Night, Patrick. |
| 00:31:20 |
Night, SpongeBob. |
| 00:31:22 |
You gotta say good |
| 00:31:23 |
Kiss SpongeBob. |
| 00:31:30 |
(SQUEAKS) |
| 00:31:32 |
Good night. |
| 00:31:35 |
Good night, Patrick. |
| 00:31:37 |
I'm not gonna say it again. |
| 00:31:41 |
It's for him. |
| 00:31:44 |
AILEEN: |
| 00:31:45 |
Me? |
| 00:31:46 |
For good luck. |
| 00:31:49 |
Oh, thank you. |
| 00:31:53 |
You like it? |
| 00:31:55 |
Well, sure. |
| 00:31:57 |
A happy-go-lucky little fellow, |
| 00:32:01 |
He's a plastic toy. |
| 00:32:03 |
I know. |
| 00:32:04 |
JOHN: |
| 00:32:06 |
You haven't lived |
| 00:32:08 |
Megan do the |
| 00:32:09 |
Here you go. |
| 00:32:11 |
Go ahead and eat |
| 00:32:13 |
Smells great, honey. |
| 00:32:15 |
(LAUGHS) |
| 00:32:17 |
Bob, we went to |
| 00:32:20 |
All right if |
| 00:32:21 |
You got a check for |
| 00:32:23 |
hell, you can |
| 00:32:25 |
(CHUCKLES) |
| 00:32:29 |
I'll just... |
| 00:32:41 |
Well, Bob. |
| 00:32:43 |
This is the first installment against |
| 00:33:00 |
Tell you the truth, |
| 00:33:02 |
Dr. Stonehill, |
| 00:33:06 |
Yeah, I know. |
| 00:33:07 |
I know. I know. |
| 00:33:11 |
You can learn a lot about a person |
| 00:33:14 |
Learn about a working-class kid |
| 00:33:18 |
worked his way through |
| 00:33:21 |
clawing his way up the ladder |
| 00:33:24 |
But what Google |
| 00:33:25 |
is that this scared, desperate, |
| 00:33:28 |
Wait just a minute... |
| 00:33:30 |
Will do and say whatever it takes |
| 00:33:34 |
Which is why you |
| 00:33:36 |
into business |
| 00:33:38 |
Excuse me? |
| 00:33:39 |
I'm tired of begging breadcrumbs |
| 00:33:41 |
and giving them |
| 00:33:44 |
They don't value |
| 00:33:48 |
which is why I'm |
| 00:33:50 |
Figure any dude |
| 00:33:52 |
can help me raise venture capital |
| 00:33:54 |
but who's gonna be |
| 00:33:56 |
a dad who's trying |
| 00:33:59 |
So, this is... |
| 00:34:01 |
So this is the shittiest offer |
| 00:34:03 |
I can promise you less money, |
| 00:34:07 |
plus, if we raise the money, you're |
| 00:34:11 |
(SCOFFS) |
| 00:34:15 |
Oh, and with |
| 00:34:18 |
I can also promise you a working |
| 00:34:22 |
I can't cure your kids, |
| 00:34:24 |
They're always |
| 00:34:28 |
but I think I can save their lives. |
| 00:34:35 |
Outstanding cobbler. |
| 00:34:40 |
AILEEN: Okay, okay. |
| 00:34:45 |
What if Stonehill fails? |
| 00:34:51 |
Or what if he succeeds too late |
| 00:34:55 |
Then what? |
| 00:34:57 |
I know. |
| 00:34:58 |
If we're gonna |
| 00:35:00 |
you want to spend every |
| 00:35:10 |
John, that day that |
| 00:35:14 |
when you suddenly |
| 00:35:20 |
My God, I thought you'd lost it. |
| 00:35:24 |
But once we |
| 00:35:27 |
and we started fundraising and |
| 00:35:34 |
it made me feel like... |
| 00:35:37 |
I mean, do we |
| 00:35:39 |
and do what we're told by |
| 00:35:44 |
and wait for the worst to happen, |
| 00:35:50 |
PETE: I think you're making |
| 00:35:55 |
Even if you were credible as a CEO, |
| 00:36:00 |
the odds against |
| 00:36:02 |
9 out of 10 |
| 00:36:05 |
So where does that leave your kids |
| 00:36:10 |
with no job and no |
| 00:36:14 |
Now, if you |
| 00:36:15 |
the guys upstairs |
| 00:36:17 |
the VP slot at the end of |
| 00:36:19 |
with a 40% salary bump. |
| 00:36:22 |
John. |
| 00:36:26 |
Your family's gonna need that money, |
| 00:36:28 |
Pete, you're right. |
| 00:36:33 |
I'm chasing the wind. |
| 00:36:36 |
But I can't just |
| 00:36:40 |
sit around and wait |
| 00:36:45 |
I can't do it. |
| 00:37:09 |
AUTOMATED VOICE: You have |
| 00:37:27 |
Come on in. It's open. |
| 00:37:30 |
Hey, there, Bob. |
| 00:37:31 |
How are you? |
| 00:37:33 |
No problem. |
| 00:37:35 |
Sit down. |
| 00:37:43 |
Ex-wife. She loved cats. |
| 00:37:50 |
Well, say, what do we... |
| 00:37:55 |
What are we gonna do? |
| 00:37:59 |
for the meeting at |
| 00:38:04 |
We don't need to show |
| 00:38:07 |
The meeting's a formality. |
| 00:38:08 |
George Renzler and I have known |
| 00:38:11 |
He's been telling me for years that |
| 00:38:16 |
if I ever decide to make the big move |
| 00:38:20 |
Well, that's good. |
| 00:38:21 |
but, still, all the same, you know, |
| 00:38:22 |
if we're gonna go in to pitch 'em, |
| 00:38:23 |
we should have something tangible. |
| 00:38:25 |
Those guys understand me. |
| 00:38:30 |
They're not like a lot of these |
| 00:38:33 |
Okay. All right, tell you what, |
| 00:38:36 |
how about if we just talk it through, |
| 00:38:37 |
and then that way we can just sketch up |
| 00:38:40 |
You give it to me, |
| 00:38:51 |
JOHN: |
| 00:38:52 |
These guys are venture capitalists. |
| 00:38:55 |
That rough enough for you? |
| 00:39:00 |
Bob? Look, Renzler's |
| 00:39:01 |
Without them onboard, |
| 00:39:03 |
with any of our investors. |
| 00:39:04 |
Whip up some business bullshit |
| 00:39:07 |
I'm going fishing. |
| 00:39:08 |
This is... This is gibberish! |
| 00:39:11 |
Then you better get busy. |
| 00:39:13 |
See you. |
| 00:39:33 |
JOHN: |
| 00:39:35 |
for an orphan drug is enormous. |
| 00:39:38 |
If you were still in business school, |
| 00:39:41 |
for all these lovely |
| 00:39:46 |
But school is out. |
| 00:39:48 |
Most of us here are scientists. |
| 00:39:50 |
We need to see the science. |
| 00:39:52 |
Bob, make us believe. |
| 00:39:58 |
Love to, George. |
| 00:40:04 |
(INAUDIBLE) |
| 00:40:14 |
...the phosphotransferase and |
| 00:40:24 |
STONEHILL: At this point, |
| 00:40:27 |
to produce kilogram |
| 00:40:30 |
And the question is |
| 00:40:32 |
to contract this work out or to build |
| 00:40:36 |
Either way, we're gonna |
| 00:40:39 |
an investment on |
| 00:40:42 |
It's a lot of information |
| 00:40:45 |
Does anybody |
| 00:40:47 |
This is astonishing. |
| 00:40:49 |
This man is light years |
| 00:40:52 |
(CHUCKLES) |
| 00:40:54 |
Well, why don't you have your |
| 00:40:57 |
and work out |
| 00:40:58 |
Sounds great. |
| 00:40:59 |
Of course, we'll need you to explain |
| 00:41:02 |
some of the mundane stuff, Bob, |
| 00:41:06 |
Nuts and bolts? What... |
| 00:41:08 |
You're a brilliant |
| 00:41:10 |
but you've never actually |
| 00:41:12 |
to market |
| 00:41:14 |
No, I've never brought a drug to market. |
| 00:41:16 |
(CLEARS THROAT) |
| 00:41:19 |
how are you getting |
| 00:41:22 |
I'm purifying it out of |
| 00:41:26 |
I see. And where are |
| 00:41:31 |
From the stockyards. |
| 00:41:33 |
Pretty straightforward stuff. |
| 00:41:35 |
Not really. |
| 00:41:36 |
You can't inject cow |
| 00:41:38 |
I know that. |
| 00:41:39 |
The bovine version |
| 00:41:41 |
is for lab work, |
| 00:41:43 |
I'll make a copy of the human enzyme |
| 00:41:47 |
What about uncovering enzyme? |
| 00:41:49 |
How exactly do you plan |
| 00:41:51 |
I'm making it in T-293, |
| 00:41:55 |
Oh, my goodness. No. |
| 00:41:56 |
"Oh, my goodness. No?" |
| 00:41:58 |
No. The FDA will |
| 00:42:00 |
Hey, Bob, just... |
| 00:42:03 |
For Christ's sake, we will change |
| 00:42:05 |
the cell line before clinical trials. |
| 00:42:07 |
You've gotta have |
| 00:42:09 |
long, long before |
| 00:42:10 |
Bob, why don't we just |
| 00:42:12 |
Why are you |
| 00:42:13 |
I don't want any goddamn coffee. |
| 00:42:15 |
Bob, can you just tell us |
| 00:42:17 |
the 3 enzymes under |
| 00:42:21 |
I'm not here to cross every "t" |
| 00:42:24 |
And I'm not here to |
| 00:42:26 |
like a 1st-year med student. |
| 00:42:28 |
This is ridiculous. |
| 00:42:30 |
Bob. |
| 00:42:32 |
This is bullshit. |
| 00:42:40 |
RENZLER: |
| 00:42:47 |
Bob, if you can't |
| 00:42:49 |
you say you're |
| 00:42:51 |
You don't storm out |
| 00:42:53 |
like some sort of |
| 00:42:55 |
Now, we're gonna |
| 00:42:56 |
No, I'm not going |
| 00:42:58 |
We're going back in there. |
| 00:43:01 |
That was personal. |
| 00:43:11 |
Stonehill goes and completely |
| 00:43:14 |
Thank you. |
| 00:43:15 |
I mean, he completely blew my plan, |
| 00:43:18 |
Okay, I get that |
| 00:43:19 |
but do you still |
| 00:43:21 |
Honey, if I don't raise |
| 00:43:26 |
his science doesn't |
| 00:43:34 |
What's going on |
| 00:43:37 |
Hey, buddy, you okay? |
| 00:43:43 |
You all right? |
| 00:43:47 |
When did this happen? |
| 00:43:49 |
I don't know. |
| 00:43:51 |
You should help him, Daddy. |
| 00:43:53 |
That's a good idea. |
| 00:43:54 |
Okay, here we go. You ready? |
| 00:43:56 |
1, 2... |
| 00:43:59 |
Into the water. |
| 00:44:01 |
That was a good shot. |
| 00:44:04 |
Try again. |
| 00:44:08 |
Here, ducky, ducky. |
| 00:44:12 |
(ALL LAUGHING) |
| 00:44:16 |
Let's do it again. |
| 00:44:18 |
Ready? 1, 2, 3. |
| 00:44:20 |
Give me another piece, John. |
| 00:44:22 |
(CHUCKLING) |
| 00:44:23 |
I can just throw them. |
| 00:44:27 |
And you do all the laughing, |
| 00:44:31 |
JOHN: |
| 00:44:33 |
Did you see that? |
| 00:44:42 |
John? |
| 00:44:46 |
We're out of time. |
| 00:44:48 |
I know. |
| 00:44:51 |
He doesn't have the strength to |
| 00:44:59 |
It scares the hell out of me. |
| 00:45:01 |
Me, too. |
| 00:45:04 |
John, what are you doing? |
| 00:45:07 |
I'm offering Renzler |
| 00:45:36 |
Excuse me. |
| 00:45:39 |
Dr. Renzler? |
| 00:45:41 |
Sir, good morning. |
| 00:45:43 |
John Crowley. |
| 00:45:45 |
Yes, sir. |
| 00:45:46 |
Good morning. |
| 00:45:47 |
I understand from |
| 00:45:48 |
you're going to be |
| 00:45:50 |
for a month. |
| 00:45:51 |
I have a proposal for you, |
| 00:45:53 |
that you could |
| 00:45:54 |
We're running |
| 00:45:55 |
I appreciate that. It'll only take a second, |
| 00:45:59 |
Fine. I'll read it in the car. |
| 00:46:01 |
Good, thank you. |
| 00:46:18 |
Does Stonehill know about this? |
| 00:46:20 |
Of course. |
| 00:46:22 |
And he's okay with these terms? |
| 00:46:26 |
All I need is your signature. |
| 00:46:54 |
Hello? |
| 00:46:55 |
* I just need some place |
| 00:46:58 |
* Where I can lay my head |
| 00:47:03 |
Bob. |
| 00:47:07 |
Bob. |
| 00:47:09 |
(KNOCKING ON WINDOW) |
| 00:47:10 |
JOHN: |
| 00:47:12 |
Over here. |
| 00:47:15 |
Bob. |
| 00:47:17 |
Ow! |
| 00:47:21 |
Bob! |
| 00:47:22 |
(THE WEIGHT PLAYING) |
| 00:47:24 |
Hi. Bob. |
| 00:47:35 |
What'd you do to yourself? |
| 00:47:37 |
I got the investment from Renzler. |
| 00:47:39 |
You what? |
| 00:47:41 |
Listen, I want you to |
| 00:47:45 |
think about something |
| 00:47:46 |
What the hell is this? |
| 00:47:47 |
Under the circumstances, this is |
| 00:47:52 |
This isn't a deal. |
| 00:47:57 |
Renzler comes in for |
| 00:47:59 |
and you give him the option |
| 00:48:02 |
Well, after sabotaging our meeting, |
| 00:48:04 |
I had to do something dramatic. |
| 00:48:05 |
And you promise him we'll be |
| 00:48:09 |
We can do this, Bob. |
| 00:48:11 |
We work harder, we push ourselves, |
| 00:48:13 |
I already work around the clock! |
| 00:48:16 |
Why don't you just give 'em |
| 00:48:19 |
There's no other way I could get |
| 00:48:21 |
Who needs the bastards anyway! |
| 00:48:24 |
Without Renzler, |
| 00:48:26 |
to even think about |
| 00:48:28 |
Fine! Then I won't think about |
| 00:48:31 |
Great! |
| 00:48:33 |
Spend the rest of |
| 00:48:35 |
great ideas that |
| 00:48:38 |
Draw brilliant diagrams on the wall |
| 00:48:43 |
but never help a single |
| 00:49:21 |
What'd you do? |
| 00:49:23 |
It's just barely... |
| 00:49:31 |
Put pressure on it. |
| 00:49:40 |
Got your blood |
| 00:49:43 |
Want me to add a drop of mine, |
| 00:49:49 |
Or would a |
| 00:50:05 |
Bob? |
| 00:50:13 |
(THE WEIGHT CONTINUES PLAYING) |
| 00:50:20 |
* I picked up my bag |
| 00:50:23 |
* I went lookin' for |
| 00:50:27 |
* When I saw Carmen and |
| 00:50:34 |
* I said, "Hey, Carmen, come on, |
| 00:50:41 |
* She said, "I gotta go, |
| 00:50:47 |
* Take a load off, Fanny |
| 00:50:51 |
I'm not paying a dollar more |
| 00:50:55 |
I'm not doing it. |
| 00:50:58 |
Hi, Bob. |
| 00:51:05 |
These guys |
| 00:51:09 |
Scientists get all sensible and |
| 00:51:13 |
Young ones like risk, |
| 00:51:15 |
not afraid of new ideas, |
| 00:51:20 |
and you can pay 'em less. |
| 00:51:25 |
We all believe in Bob Stonehill's |
| 00:51:27 |
bold vision, otherwise |
| 00:51:30 |
But to reach clinical |
| 00:51:34 |
I'm gonna have to ask you |
| 00:51:39 |
Ladies and gentlemen, |
| 00:51:49 |
How long? |
| 00:51:50 |
3, 4 hours. |
| 00:51:56 |
Well, if you can get it any quicker, |
| 00:51:59 |
NILES: |
| 00:52:09 |
MAN: |
| 00:52:11 |
STONEHILL: Vinh, check the breakers. |
| 00:52:15 |
(SWITCH CLICKING) |
| 00:52:17 |
VINH: |
| 00:52:19 |
Well, get the backup |
| 00:52:22 |
We... |
| 00:52:25 |
STONEHILL: You never bothered |
| 00:52:28 |
We're in the middle |
| 00:52:29 |
for Christ's sake! |
| 00:52:31 |
If I don't have my |
| 00:52:33 |
in 45 minutes, |
| 00:52:36 |
4 months of work pissed away! |
| 00:52:38 |
It was never in the budget. |
| 00:52:43 |
I'm sorry, sir. |
| 00:52:45 |
What? |
| 00:52:47 |
It got maxed out. I bought |
| 00:52:51 |
Shit, I... |
| 00:52:56 |
Just pay me back by the end of the month, |
| 00:53:00 |
Hi, here you go. Thanks. |
| 00:53:05 |
Yes! |
| 00:53:09 |
Yes! |
| 00:53:14 |
DRIVER: |
| 00:53:18 |
Thank you. |
| 00:53:31 |
Fiona's in Mexico this week. |
| 00:53:35 |
Mmm-hmm. |
| 00:53:37 |
She's still got lots of things to see |
| 00:53:38 |
before she gets to Antarctica. |
| 00:53:41 |
Yeah. |
| 00:53:47 |
She's gonna chop up all the |
| 00:53:50 |
And feed their bloody remains |
| 00:53:54 |
I see. |
| 00:53:57 |
What? |
| 00:53:58 |
Every time you come home for the weekend, |
| 00:54:02 |
Megs. |
| 00:54:04 |
You know what, |
| 00:54:07 |
It's just that |
| 00:54:09 |
trying to make the special medicine |
| 00:54:12 |
I want it pink. |
| 00:54:15 |
You want what? |
| 00:54:17 |
I want it to be pink. |
| 00:54:20 |
Okay. I guess I can |
| 00:54:23 |
Tell him dark pink, |
| 00:54:26 |
Not light pink. |
| 00:54:30 |
Okay. |
| 00:54:35 |
SCIENTIST: |
| 00:54:36 |
Dr. Renzler, be reasonable. |
| 00:54:39 |
and we are making great progress |
| 00:54:43 |
I don't know. |
| 00:54:45 |
Well, we've got to get |
| 00:54:48 |
You know that Zymagen has far |
| 00:54:51 |
So, what you're saying, |
| 00:54:54 |
No, what I'm saying is, is that |
| 00:54:57 |
Either that, or scare |
| 00:54:59 |
Well, you're scaring us investors |
| 00:55:01 |
a hell of a lot more than |
| 00:55:04 |
You sell the company |
| 00:55:06 |
you're in clinical trials |
| 00:55:09 |
or we pull the plug and cut our losses. |
| 00:55:15 |
Hello? |
| 00:55:25 |
This construct's |
| 00:55:28 |
but we gotta get |
| 00:55:29 |
between the alpha |
| 00:55:33 |
Well, what if we |
| 00:55:34 |
like the one in |
| 00:55:36 |
Why would you wanna do that? |
| 00:55:38 |
We need to talk. |
| 00:55:39 |
I'm busy. |
| 00:55:41 |
You always wanna talk. |
| 00:55:42 |
Yeah, we could add furin and try |
| 00:55:46 |
(CLEARS THROAT) |
| 00:55:49 |
What are you doing? |
| 00:55:51 |
Giving you a preview... |
| 00:55:52 |
Guys, would you |
| 00:55:53 |
of what's going to happen if we |
| 00:55:57 |
Our investors will |
| 00:56:03 |
Science takes time, Jersey. |
| 00:56:06 |
Yeah, they do. |
| 00:56:08 |
They see that Zymagen is testing |
| 00:56:12 |
They're testing 3 'cause they don't |
| 00:56:14 |
I'm testing one 'cause it's the right one! |
| 00:56:17 |
I know. I believe you, Bob. |
| 00:56:19 |
Why else do you think |
| 00:56:22 |
Look. |
| 00:56:25 |
I want you to go toe-to-toe |
| 00:56:30 |
Prove to them that |
| 00:56:33 |
I can do that. |
| 00:56:34 |
That's the reason I've entered |
| 00:56:37 |
to buy our company. |
| 00:56:39 |
You're telling me? |
| 00:56:41 |
Oh, come on, Bob. |
| 00:56:46 |
Nobody is gonna tell me |
| 00:56:50 |
If I can engineer a deal, |
| 00:56:53 |
you're going to |
| 00:56:54 |
for all the money |
| 00:56:56 |
I don't care about money. |
| 00:56:58 |
I'm a scientist. I care about |
| 00:57:02 |
Don't you tell me about more |
| 00:57:08 |
Do the math. |
| 00:57:10 |
Either we sell the company |
| 00:57:17 |
or the investors |
| 00:57:30 |
Where you going? |
| 00:57:36 |
I'm gonna go take a crap, |
| 00:57:59 |
What, they can't drive from |
| 00:58:03 |
Bob, we need to |
| 00:58:07 |
They're gonna ask us |
| 00:58:10 |
Don't take 'em personally, all right? |
| 00:58:26 |
STONEHILL: These lab results confirm |
| 00:58:29 |
that phosphorylation is key |
| 00:58:34 |
My theory works for Pompe, |
| 00:58:36 |
and eventually it'll work for |
| 00:58:40 |
for other lysosomal |
| 00:58:44 |
Is it too complicated? |
| 00:58:46 |
Too complicated? |
| 00:58:47 |
The number of |
| 00:58:49 |
your approach |
| 00:58:51 |
I mean, Jesus, |
| 00:58:53 |
in the synthesis, |
| 00:58:55 |
just one carbohydrate |
| 00:58:58 |
Well, it's gotta be done right, |
| 00:59:02 |
You've never actually gotten |
| 00:59:04 |
Isn't it naive to |
| 00:59:07 |
these kinds of |
| 00:59:15 |
(MOUTHING) |
| 00:59:19 |
You're right, I'm a theory guy. |
| 00:59:22 |
My head is in the clouds. |
| 00:59:26 |
Which is why we need you. |
| 00:59:31 |
Unless, of course, |
| 00:59:34 |
protein-manufacturing |
| 00:59:37 |
(CHUCKLES) |
| 00:59:40 |
Nice one. |
| 00:59:42 |
I still need to hear |
| 00:59:45 |
JOHN: |
| 00:59:47 |
As you know, this is not a one-time |
| 00:59:53 |
And these patients, |
| 00:59:55 |
they are going to |
| 00:59:59 |
over the span of |
| 01:00:01 |
But even if you |
| 01:00:02 |
clearly it won't work for all patients. |
| 01:00:05 |
So, what survival rate do we need |
| 01:00:09 |
What rate of patient death |
| 01:00:14 |
Acceptable loss? |
| 01:00:21 |
I understand the question. |
| 01:00:26 |
Because the profit margins |
| 01:00:29 |
are so incredibly high, the... |
| 01:00:33 |
Even with |
| 01:00:35 |
say, 25% over 5 years still indicates |
| 01:00:39 |
that there is a highly lucrative |
| 01:00:42 |
revenue source to be realized. |
| 01:01:00 |
Gentlemen, we have a deal. |
| 01:01:50 |
Dr. Robert Stonehill |
| 01:01:57 |
GUARD: I have a Dr. Robert Stonehill |
| 01:02:02 |
Sir, you need to be cleared. |
| 01:02:03 |
I'm just gonna use the restroom. |
| 01:02:05 |
You need to be cleared to do that, sir. |
| 01:02:06 |
Just need to... |
| 01:02:08 |
You need a security badge. |
| 01:02:10 |
Jesus. |
| 01:02:15 |
Well, can I have a security badge |
| 01:02:19 |
Yes, sir. |
| 01:02:29 |
Hey, Bob. |
| 01:02:31 |
Hey, John. |
| 01:02:34 |
Define "comfortable." |
| 01:02:41 |
You haven't cashed it yet? |
| 01:02:44 |
I haven't earned it yet. |
| 01:02:47 |
I'll cash it when we |
| 01:03:08 |
Well, it sure is beautiful. |
| 01:03:13 |
(KIDS SHOUTING) |
| 01:03:17 |
It sure is big. |
| 01:03:20 |
The kids love it. |
| 01:03:29 |
Seize the day. |
| 01:03:35 |
Okay. |
| 01:03:40 |
(SPEAKING IN FRENCH) |
| 01:03:47 |
I'm stuck on this call. |
| 01:03:49 |
Just wanted to let |
| 01:03:50 |
we are to have |
| 01:03:52 |
It's an honor. |
| 01:03:54 |
You remember Dr. Kent Webber. |
| 01:03:57 |
It's good to see you again. |
| 01:03:58 |
I'll let the 2 of you get into it. |
| 01:04:01 |
I'm expecting great things. |
| 01:04:03 |
Yes, sir. |
| 01:04:06 |
(SPEAKING IN FRENCH) |
| 01:04:08 |
I've got some pretty good ideas |
| 01:04:11 |
about how to help |
| 01:04:13 |
between the 4 core enzyme groups. |
| 01:04:15 |
Whoa, John, slow down. |
| 01:04:19 |
Pardon me? |
| 01:04:20 |
The 4 core teams are essentially |
| 01:04:22 |
in competition with each other. |
| 01:04:24 |
It's an entrepreneurial |
| 01:04:27 |
I'm all for competition, |
| 01:04:32 |
for allowing sharing |
| 01:04:35 |
that can help develop |
| 01:04:39 |
John, in the interest of saving us time, |
| 01:04:45 |
Most of the scientists |
| 01:04:47 |
of having a non-scientist |
| 01:04:53 |
Especially one whose objectivity |
| 01:04:55 |
might be clouded by having children |
| 01:05:00 |
I'm telling you this in your own |
| 01:05:03 |
Erich wanted to buy |
| 01:05:06 |
and he couldn't do |
| 01:05:08 |
swallowing you as |
| 01:05:13 |
My advice to you, John, |
| 01:05:20 |
Thank you for that wisdom. |
| 01:05:22 |
You're very welcome. |
| 01:05:28 |
SCIENTIST: All of your lab notebooks must |
| 01:05:31 |
STONEHILL: |
| 01:05:34 |
I'm just trying to |
| 01:05:36 |
STONEHILL: |
| 01:05:38 |
Dr. Stonehill... |
| 01:05:40 |
Fine. |
| 01:05:47 |
What do you want? |
| 01:05:49 |
I just dropped by |
| 01:05:52 |
that we might be |
| 01:05:54 |
to open a dialogue with |
| 01:05:57 |
The other core teams? |
| 01:06:01 |
Core bullshit. |
| 01:06:03 |
I'll come back another time. |
| 01:06:09 |
DR. WALDMAN: The decline in muscle |
| 01:06:12 |
but it's really, |
| 01:06:16 |
the organ enlargement, the liver, |
| 01:06:20 |
that's the real |
| 01:06:24 |
We'll continue to monitor |
| 01:06:27 |
We'll keep tabs on |
| 01:06:29 |
How long? |
| 01:06:32 |
I don't like to predict. |
| 01:06:35 |
Dr. Waldman, |
| 01:06:37 |
We just need to |
| 01:06:38 |
John. |
| 01:06:40 |
How much more time do we have? |
| 01:06:45 |
Well, |
| 01:06:50 |
if there's another respiratory crisis, |
| 01:06:54 |
but otherwise, |
| 01:07:00 |
Megan, maybe a year. |
| 01:07:02 |
Patrick, less. |
| 01:07:08 |
Thank you. |
| 01:07:24 |
(PHONE RINGING) |
| 01:07:25 |
WENDY: Marcus. |
| 01:07:26 |
Get the phone. |
| 01:07:27 |
The phone. |
| 01:07:30 |
MARCUS: |
| 01:07:31 |
Hi. Is that Marcus? |
| 01:07:33 |
Yeah, yeah. |
| 01:07:34 |
Yeah, I'm sorry. It's late. |
| 01:07:37 |
It's John Crowley. |
| 01:07:39 |
John, what you doin'? |
| 01:07:41 |
You okay? |
| 01:07:43 |
(SIGHS) |
| 01:07:44 |
Hey, look, |
| 01:07:49 |
Morning, Gavin. |
| 01:07:51 |
Is my 11:00 with |
| 01:07:53 |
Yes, and there's the breakfast |
| 01:07:56 |
Breakfast meeting? |
| 01:07:58 |
There was an e-mail that |
| 01:08:01 |
Everyone on the Pompe |
| 01:08:02 |
Who called the meeting? |
| 01:08:04 |
Mr. Crowley, I believe, sir. |
| 01:08:06 |
What? |
| 01:08:11 |
AILEEN: Um, something |
| 01:08:13 |
is how we have 2 kids with Pompe. |
| 01:08:17 |
By the time we realized |
| 01:08:22 |
I was already pregnant |
| 01:08:24 |
I mean, I can't tell you |
| 01:08:27 |
and the message |
| 01:08:29 |
that there is no drug |
| 01:08:32 |
But thanks to you, all of you, |
| 01:08:36 |
What you've given us, |
| 01:08:41 |
So, thank you. |
| 01:08:43 |
Good job, Aileen. |
| 01:08:48 |
Now I'd like to |
| 01:08:51 |
who've come all the way from Georgia |
| 01:09:01 |
Thanks, John. |
| 01:09:06 |
Hi. |
| 01:09:09 |
I'm Marcus. |
| 01:09:11 |
This is my wife, Wendy. |
| 01:09:14 |
Our daughter Lauren, |
| 01:09:17 |
Lauren wanted to come today |
| 01:09:24 |
She's a little weak, |
| 01:09:25 |
but she wanted us to show |
| 01:09:31 |
and to send you her love. |
| 01:09:34 |
And this is our daughter, Megan. |
| 01:09:38 |
The most beautiful |
| 01:09:42 |
Megan is 4 months old, |
| 01:09:48 |
but she has Pompe, too. |
| 01:10:04 |
I... |
| 01:10:07 |
I can't tell you what it means to us |
| 01:10:13 |
to have all of you working on |
| 01:10:20 |
Thank you. |
| 01:10:28 |
Thanks so much. |
| 01:10:38 |
Hey, Kent. |
| 01:10:41 |
JOHN: |
| 01:10:49 |
In medical research, John, |
| 01:10:56 |
If researchers get all emotional, |
| 01:10:59 |
all desperate to help suffering patients, |
| 01:11:03 |
It's counterproductive. |
| 01:11:05 |
Counterproductive is having |
| 01:11:10 |
working together |
| 01:11:12 |
but not talking to each other. |
| 01:11:15 |
Most of these guys have never even |
| 01:11:18 |
I don't see how |
| 01:11:20 |
Did you see Erich? That's the kind |
| 01:11:24 |
I'm gonna ask him |
| 01:11:26 |
to stop competing, |
| 01:11:29 |
Create a leadership team. |
| 01:11:33 |
Well, if you hope to sell |
| 01:11:37 |
there's only one |
| 01:11:39 |
And what's that? |
| 01:11:40 |
Keep your guy, |
| 01:11:44 |
In his short tenure here, |
| 01:11:47 |
a remarkable number |
| 01:11:50 |
You can't put him on a team that's |
| 01:11:53 |
So, decide how badly |
| 01:11:59 |
then do what you have to do. |
| 01:12:09 |
(ROCK MUSIC PLAYING) |
| 01:12:13 |
That's it. |
| 01:12:20 |
Dr. Stonehill, please. |
| 01:12:23 |
Turn it down. Yes. |
| 01:12:26 |
Yes, the music. |
| 01:12:28 |
(VOLUME INCREASES) |
| 01:12:31 |
I said down! |
| 01:12:34 |
This guy's impossible. |
| 01:12:36 |
I like that song. |
| 01:12:45 |
JOHN: |
| 01:12:52 |
What's up, John? |
| 01:12:54 |
Everything all right at home? |
| 01:12:57 |
Yeah. |
| 01:13:01 |
Have you heard that Erich Loring |
| 01:13:03 |
has agreed to put together |
| 01:13:08 |
Yeah, I heard some rumor about it. |
| 01:13:10 |
Now I'm gonna have to spend |
| 01:13:13 |
jawin' with Zymagen guys? |
| 01:13:16 |
No. |
| 01:13:18 |
No. No, you won't, 'cause |
| 01:13:22 |
What'd you say? |
| 01:13:24 |
I really wanted to. |
| 01:13:27 |
You're not putting me on the team? |
| 01:13:30 |
What are you, |
| 01:13:33 |
They didn't buy our company |
| 01:13:35 |
'cause they like your |
| 01:13:39 |
It's me they wanted. |
| 01:13:41 |
You can't bench me. |
| 01:13:44 |
You're still gonna be able to |
| 01:13:49 |
Yeah, but other |
| 01:13:51 |
evaluate my results, |
| 01:13:54 |
Everyone here |
| 01:13:58 |
This is about |
| 01:14:04 |
Who put you up to this? |
| 01:14:06 |
The decision was mine. |
| 01:14:10 |
It's for the overall |
| 01:14:13 |
"For the overall |
| 01:14:17 |
Wow, John, you really got |
| 01:14:19 |
What's next, "Acceptable loss?" |
| 01:14:38 |
JOHN JR.: |
| 01:14:40 |
JOHN: Does anybody really |
| 01:14:41 |
Except for us. |
| 01:14:44 |
But wait, who's going? |
| 01:14:46 |
MEGAN: |
| 01:14:49 |
(KIDS EXCLAIMING) |
| 01:14:50 |
(PHONE RINGING) |
| 01:14:52 |
Okay. I'll get it. |
| 01:15:00 |
Nice one, Megs. |
| 01:15:02 |
Hello? Marcus, hi. |
| 01:15:06 |
Oh, my God. |
| 01:15:07 |
PATRICK: |
| 01:15:09 |
You guys sit tight, okay? |
| 01:15:13 |
If there is anything we can do, |
| 01:15:15 |
will you call? |
| 01:15:18 |
Okay. We love |
| 01:15:22 |
Okay, bye-bye. |
| 01:15:26 |
Aileen. |
| 01:15:30 |
That was Marcus Temple. |
| 01:15:33 |
Lauren... |
| 01:15:35 |
She... |
| 01:15:40 |
He said she went in her sleep, |
| 01:15:43 |
JOHN JR.: |
| 01:15:46 |
How old was Lauren? |
| 01:15:53 |
Lauren was 9 years old. |
| 01:16:03 |
Come here. |
| 01:16:15 |
JOHN: That way, we can be certain that |
| 01:16:19 |
Forget certainty, |
| 01:16:22 |
which enzyme has |
| 01:16:25 |
If we develop |
| 01:16:29 |
what would happen |
| 01:16:31 |
Mr. Crowley, I've asked Kent |
| 01:16:36 |
to help us guess right. |
| 01:16:39 |
We'll do an exhaustive |
| 01:16:42 |
I'm calling it |
| 01:16:46 |
(ALL CHUCKLING) |
| 01:16:48 |
The 4 enzymes |
| 01:16:50 |
yellow, blue, |
| 01:16:52 |
and known only by |
| 01:16:55 |
so no researcher will know |
| 01:16:58 |
Only after we pick a winner, |
| 01:17:09 |
GIRL: |
| 01:17:22 |
GIRL: |
| 01:17:29 |
JOHN: |
| 01:17:30 |
I can't. |
| 01:17:36 |
It's okay. It's all right. |
| 01:17:38 |
Okay. Let's try again. Ready? |
| 01:17:43 |
Ready? |
| 01:17:44 |
1, 2, 3, go! |
| 01:17:47 |
(KIDS CHEERING) |
| 01:17:49 |
Big winner! |
| 01:17:52 |
Here you go, look at that. |
| 01:17:57 |
(ROCK MUSIC PLAYING) |
| 01:18:05 |
JOHN: |
| 01:18:09 |
How you doin'? |
| 01:18:17 |
I brought you some ribs. |
| 01:18:19 |
Not as good as the ones |
| 01:18:23 |
but if you're hungry... |
| 01:18:34 |
(MUSIC STOPS) |
| 01:18:36 |
What do you want? |
| 01:18:40 |
The results. |
| 01:18:44 |
"Mother of All Experiments." |
| 01:18:46 |
Well, |
| 01:18:49 |
which enzyme did they choose? |
| 01:18:51 |
The leadership team spent |
| 01:18:55 |
2 enzymes, coded yellow and green, |
| 01:18:58 |
but it's too close to call. |
| 01:19:01 |
Tomorrow, we spend |
| 01:19:04 |
to decide which one to choose. |
| 01:19:08 |
Bob. I'm asking you to read this. |
| 01:19:12 |
I value your opinion more than |
| 01:19:16 |
Well, maybe you should have valued |
| 01:19:18 |
instead of playing hatchet man |
| 01:19:23 |
Get the hell out of my lab. |
| 01:19:24 |
It's in your interest |
| 01:19:31 |
Get out. |
| 01:19:32 |
Wouldn't it benefit you... |
| 01:19:59 |
The green enzyme's the best. |
| 01:20:05 |
Hey, wait up, Bob. |
| 01:20:08 |
Is the green enzyme yours? |
| 01:20:10 |
I recognize patterns |
| 01:20:11 |
I'd know my baby |
| 01:20:14 |
So the green one is yours? |
| 01:20:17 |
No, it's not. |
| 01:20:21 |
My theory is still the best, |
| 01:20:26 |
Theirs is crude and uninspired, |
| 01:20:31 |
Bob, I don't even know |
| 01:20:36 |
Don't bother. |
| 01:20:39 |
I didn't do it for you. |
| 01:21:28 |
JOHN JR.: |
| 01:21:32 |
Oh, my gosh. |
| 01:21:34 |
Yeah. |
| 01:21:36 |
JOHN: |
| 01:21:38 |
Building a bastion. |
| 01:21:39 |
AILEEN: |
| 01:21:44 |
(PHONE RINGING) |
| 01:21:45 |
3! |
| 01:21:46 |
Dad, like... |
| 01:21:48 |
Dad, you promised |
| 01:21:49 |
I know. I know I did, but... |
| 01:21:52 |
We can take turns burying |
| 01:21:55 |
Okay! I'll start digging a hole. |
| 01:21:56 |
You hold that for a sec. |
| 01:21:58 |
John Crowley. |
| 01:21:59 |
John, it's Kent Weber. |
| 01:22:01 |
Kent, hey. Did you get my suggested |
| 01:22:06 |
Yeah. |
| 01:22:09 |
You made some pretty |
| 01:22:11 |
about where our |
| 01:22:14 |
I see. |
| 01:22:16 |
Well, what do you think |
| 01:22:21 |
John, I'll give to you straight. |
| 01:22:24 |
The clinical trial |
| 01:22:27 |
(EXCLAIMS) |
| 01:22:28 |
Infants need so |
| 01:22:30 |
and, as you know, |
| 01:22:34 |
And the drug has much higher |
| 01:22:38 |
with infants than |
| 01:22:40 |
We have to consult Erich on this. |
| 01:22:44 |
I already did. He confirmed |
| 01:22:48 |
I understand your |
| 01:22:52 |
(SIGHS) |
| 01:22:54 |
These decisions have to be |
| 01:23:00 |
I'm sorry. I... |
| 01:23:04 |
I really am. |
| 01:23:34 |
(ENGINE STARTING) |
| 01:24:34 |
(ELECTRONIC WHIRRING) |
| 01:26:18 |
GUARD: |
| 01:26:23 |
Mr. Crowley, what are you |
| 01:26:25 |
I was just... |
| 01:26:27 |
You're not authorized. |
| 01:26:28 |
No... I can |
| 01:26:31 |
What's the matter, Chuck? |
| 01:26:33 |
Yeah, there's a problem. I got |
| 01:26:36 |
That's my fault, now. |
| 01:26:38 |
I got busy in the lab, |
| 01:26:40 |
to get me a couple |
| 01:26:44 |
Sorry. |
| 01:26:55 |
Thanks, Chuck. |
| 01:27:03 |
Thanks for saving my ass. |
| 01:27:07 |
It's really big of you, |
| 01:27:09 |
especially after what |
| 01:27:15 |
You mean your ruthless, |
| 01:27:21 |
Yeah, well, when I thought |
| 01:27:26 |
Shit, if it was my |
| 01:27:28 |
have hesitated to |
| 01:27:46 |
Do you remember |
| 01:27:48 |
and you told me that |
| 01:27:53 |
and should go home |
| 01:27:58 |
while they're still here? |
| 01:28:05 |
Yeah. I made the wrong choice. |
| 01:28:23 |
Jersey, you know |
| 01:28:26 |
No. |
| 01:28:28 |
It's a drug trial with just 2 patients |
| 01:28:30 |
with the same genetic inheritance. |
| 01:28:33 |
Siblings, with the same disease. |
| 01:28:37 |
Megs and Patrick. |
| 01:28:41 |
Well, would Zymagen |
| 01:28:45 |
There's real research value in it. |
| 01:28:48 |
And with just two patients, |
| 01:28:52 |
But Webber would |
| 01:28:56 |
Well, let's not tell him till |
| 01:28:59 |
I could draw up a protocol |
| 01:29:02 |
a hospital willing |
| 01:29:06 |
Bob. |
| 01:29:12 |
It's a Hail Mary. |
| 01:29:44 |
(READING) |
| 01:29:46 |
Ducks in a row. |
| 01:29:50 |
"Stonehill, careful review, |
| 01:29:53 |
"are pleased to inform you |
| 01:29:54 |
"have been accepted |
| 01:29:56 |
I just got it. |
| 01:29:57 |
Quack, quack, quack. |
| 01:29:59 |
Have you talked to him yet? |
| 01:30:00 |
No. I did the science. |
| 01:30:06 |
Thank you. |
| 01:30:08 |
Good luck. |
| 01:30:17 |
Does he have about 5? |
| 01:30:19 |
Thanks. |
| 01:30:23 |
Hey, Kent? Knock-knock. |
| 01:30:27 |
Got a minute? |
| 01:30:31 |
Kent? |
| 01:30:33 |
Do you have any idea what you've done? |
| 01:30:37 |
We got a call this morning from |
| 01:30:40 |
about sending them |
| 01:30:42 |
Right. Yeah, I know. |
| 01:30:45 |
You and Stonehill set this up behind |
| 01:30:49 |
It's all tentative. |
| 01:30:51 |
You want this company |
| 01:30:55 |
for 2 children whose father |
| 01:31:00 |
Have you never heard the term |
| 01:31:02 |
It has nothing to do with a... |
| 01:31:03 |
Do you know what the FDA |
| 01:31:05 |
There is strong scientific justification |
| 01:31:08 |
There is great research value. |
| 01:31:10 |
I'm a doctor, John. |
| 01:31:14 |
But you guys just can't go off |
| 01:31:17 |
And I'm sure that if we just go |
| 01:31:19 |
Erich already knows. |
| 01:31:21 |
He's furious about |
| 01:31:23 |
I didn't try to |
| 01:31:25 |
This is the reason why |
| 01:31:29 |
why we have established procedure, |
| 01:31:34 |
You heartless, |
| 01:31:37 |
You just have to fight me every step |
| 01:31:41 |
You just hated it |
| 01:31:42 |
the kids with Pompe |
| 01:31:45 |
You weren't thinking |
| 01:31:46 |
when you put your |
| 01:31:49 |
and jeopardized |
| 01:31:51 |
research investment |
| 01:31:54 |
This is not about |
| 01:31:56 |
It's about kids, |
| 01:31:59 |
kids with names, dreams, |
| 01:32:03 |
families that love them. |
| 01:32:06 |
You've jeopardized |
| 01:32:08 |
of ever getting |
| 01:32:37 |
(SLAMMING) |
| 01:32:38 |
(SHOUTING) |
| 01:32:39 |
I'm not arguing |
| 01:32:43 |
On every level! |
| 01:32:57 |
(TAPPING ON DOOR) |
| 01:33:01 |
I was just drafting a letter of |
| 01:33:05 |
but I guess we're |
| 01:33:10 |
I just spoke to Erich, and we are |
| 01:33:15 |
Okay, I'll pack |
| 01:33:17 |
Just one thing, John. |
| 01:33:20 |
I may well be a tight-ass |
| 01:33:24 |
but I resent being |
| 01:33:27 |
Look... |
| 01:33:30 |
The reason we're terminating |
| 01:33:33 |
is to eliminate the |
| 01:33:36 |
This strategy was |
| 01:33:39 |
by our colleague, |
| 01:33:41 |
in rather crude terms. |
| 01:33:45 |
This will allow the sibling trial |
| 01:33:49 |
for its purely |
| 01:33:54 |
Ah. |
| 01:33:55 |
Have your desk cleared out |
| 01:34:00 |
Kent, what's with the... |
| 01:34:03 |
Oh... |
| 01:34:05 |
I wanted to make |
| 01:34:07 |
punch me out before |
| 01:34:11 |
Well, um... |
| 01:34:15 |
...thank you very |
| 01:34:17 |
My pleasure. |
| 01:34:18 |
I never liked you. |
| 01:34:20 |
Likewise. |
| 01:34:25 |
Hey, you guys, |
| 01:34:27 |
Mom! Mom! |
| 01:34:28 |
Can I bring the bow and arrow? |
| 01:34:33 |
Hey! |
| 01:34:35 |
(CHUCKLES) |
| 01:34:40 |
John, what... |
| 01:34:43 |
What? |
| 01:34:45 |
We have a usable enzyme |
| 01:34:53 |
When? When will it be ready? |
| 01:34:55 |
Megs and Patrick start their infusions |
| 01:34:59 |
Oh, my God. |
| 01:35:03 |
Oh, my God. |
| 01:35:06 |
John. |
| 01:35:08 |
Hey, John, Daddy's here. |
| 01:35:10 |
Oh, hi, guys. |
| 01:35:13 |
Why is Mommy sad? |
| 01:35:16 |
Not sad, baby, so happy. |
| 01:35:22 |
So happy. |
| 01:35:24 |
Why is Mommy being so weird? |
| 01:35:26 |
Well, it's because |
| 01:35:29 |
for you, Megs, |
| 01:35:30 |
and you're gonna |
| 01:35:32 |
(GASPS) JOHN JR.: |
| 01:35:49 |
So, who wants to |
| 01:36:05 |
JOHN: |
| 01:36:27 |
When will we know if it's working? |
| 01:36:30 |
It'll be a while, honey. |
| 01:36:32 |
It's not pink. |
| 01:37:13 |
Excuse me? |
| 01:37:17 |
Huh? |
| 01:37:18 |
I don't know. |
| 01:37:27 |
You can go back if you like. |
| 01:37:28 |
Okay. |
| 01:37:35 |
John. |
| 01:37:38 |
They wouldn't let me in |
| 01:37:44 |
Some things for the kids. |
| 01:37:46 |
Thanks. |
| 01:37:47 |
Sleeping, huh? |
| 01:37:54 |
Hey, thanks for coming. |
| 01:38:00 |
I'm a scientist. |
| 01:38:12 |
JOHN: I wish your enzyme was |
| 01:38:16 |
But the one the kids are getting, |
| 01:38:19 |
it's the right one, right? I mean... |
| 01:38:23 |
It's gonna help them. |
| 01:38:29 |
Yeah, you guys have done |
| 01:38:32 |
We just have to see |
| 01:38:39 |
JOHN: |
| 01:38:42 |
and I just want you |
| 01:38:46 |
I want you to know that... |
| 01:38:48 |
Yeah. |
| 01:38:50 |
Okay. |
| 01:38:53 |
I want you to know |
| 01:38:57 |
that you've done |
| 01:38:59 |
and I'm never gonna forget it |
| 01:39:06 |
Not gonna kiss me, is he? |
| 01:39:08 |
I will restrain him. |
| 01:39:11 |
Don't tempt me. |
| 01:39:16 |
PATRICK: Daddy loves SpongeBob, |
| 01:39:27 |
(BOTH LAUGHING) |
| 01:39:33 |
MEGAN: Stop! |
| 01:39:35 |
Guys? |
| 01:39:38 |
(CHUCKLES) |
| 01:39:41 |
What's so funny? |
| 01:39:44 |
(CHUCKLES) |
| 01:39:49 |
What are you laughing at? |
| 01:39:52 |
Sugar. |
| 01:39:57 |
It's a sugar high. |
| 01:40:00 |
The enzyme's breaking down |
| 01:40:03 |
The medicine's working? |
| 01:40:05 |
Yeah. |
| 01:40:07 |
John. |
| 01:40:17 |
Megs! |
| 01:40:19 |
Hi. |
| 01:40:21 |
(KIDS CONTINUE LAUGHING) |
| 01:40:26 |
Subtitles: ChEtAn |
| 01:40:33 |
(CHUCKLING) |
| 01:40:37 |
(CHANGE THE WORLD PLAYING) |
| 01:40:39 |
AILEEN: John, drive safe! |
| 01:40:44 |
Rock and roll! |
| 01:40:47 |
Bye! Have fun. |
| 01:40:48 |
Bye! |
| 01:40:51 |
* So you could see the truth |
| 01:40:56 |
* That this love I have inside |
| 01:41:01 |
* Is everything it seems |
| 01:41:06 |
* But for now I find |
| 01:41:11 |
* It's only in my dreams |
| 01:41:15 |
* That I can change the world |
| 01:41:21 |
* I would be the sunlight |
| 01:41:26 |
* You would think my love |
| 01:41:29 |
Yes! |
| 01:41:31 |
Yeah! Yeah! |
| 01:41:33 |
* Change the world |
| 01:41:37 |
* Baby, if I could change |
| 01:41:45 |
* The world |
